{"id":"F2018L01183","name":"Statement of Principles concerning adrenal insufficiency (Balance of Probabilities) (No. 72 of 2018)","slug":"statement-of-principles-concerning-adrenal-insufficiency-balance-of-probabilities-no-72-of-2018","collection":"legislative_instrument","jurisdiction":"commonwealth","status":"in_force","isInForce":true,"actNumber":null,"makingDate":null,"administeringDepartment":null,"currentVersion":{"id":439736,"registerId":"F2018L01183-fast-fetch-1775955645404","compilationNumber":null,"startDate":"2026-04-12","status":"InForce","reasons":null,"registeredAt":null},"sections":[{"sectionNumber":"1","sectionType":"section","heading":"Statement of Principles concerning adrenal insufficiency (Balance of Probabilities) (No. 72 of 2018)","content":"---\nmeta-content-style-type: text/css\nmeta-content-type: application/xhtml+xml; charset=utf-8\nmeta-generator: Aspose.Words for .NET 20.2\n---\n\n?xml version=\"1.0\" encoding=\"utf-8\" standalone=\"no\"?>\n\n\n\n \n\nStatement of Principles\n\nconcerning\n\nADRENAL INSUFFICIENCY (Balance of Probabilities)\n\n(No. 72 of 2018)\n\nThe Repatriation Medical Authority determines the following Statement of Principles under subsection 196B(3) of the Veterans' Entitlements Act 1986.\n\n \n\nDated 24 August 2018\n\n \n\n \n\n \n\n \n\n \n\n| The Common Seal of the Repatriation Medical Authority was affixed to this instrument at the direction of:
|\n| --- |\n|
Professor Nicholas Saunders AO
Chairperson
|\n\n\n \n\n \n\n\nContents\n\n1 Name\n\n2 Commencement\n\n3 Authority\n\n4 Repeal\n\n5 Application\n\n6 Definitions\n\n7 Kind of injury, disease or death to which this Statement of Principles relates\n\n8 Basis for determining the factors\n\n9 Factors that must exist\n\n10 Relationship to service\n\n11 Factors referring to an injury or disease covered by another Statement of Principles\n\nSchedule 1 - Dictionary\n\n2 Definitions\n\n \n\n\n\n\n1 Name\n\nThis is the Statement of Principles concerning adrenal insufficiency (Balance of Probabilities) (No. 72 of 2018).\n\n2 Commencement\n\n This instrument commences on 24 September 2018.\n\n3 Authority\n\nThis instrument is made under subsection 196B(3) of the Veterans' Entitlements Act 1986.\n\n4 Repeal\n\nThe Statement of Principles concerning adrenal insufficiency No. 75 of 2009 (Federal Register of Legislation No. F2009L04046) made under subsection 196B(3) of the VEA is repealed.\n\n5 Application\n\nThis instrument applies to a claim to which section 120B of the VEA or section 339 of the Military Rehabilitation and Compensation Act 2004 applies.\n\n6 Definitions\n\nThe terms defined in the Schedule 1 - Dictionary have the meaning given when used in this instrument.\n\n7 Kind of injury, disease or death to which this Statement of Principles relates\n\n(1) This Statement of Principles is about adrenal insufficiency and death from adrenal insufficiency.\n\nMeaning of adrenal insufficiency\n\n(2) For the purposes of this Statement of Principles, adrenal insufficiency:\n\n(a) means an endocrine disease characterised by biochemically-demonstrated deficient production of adrenal cortical hormones, sufficient to produce clinical symptoms and signs, and to necessitate glucocorticoid, mineralocorticoid or adrenal androgen replacement therapy; and\n\n(b) includes drug-induced adrenal insufficiency; and\n\n(c) excludes heritable and congenital forms of adrenal insufficiency.\n\nNote 1: Adrenal cortical hormones are mineralocorticoids, cortisol and adrenal androgens.\n\nNote 2: Clinical symptoms and signs of adrenal insufficiency are nonspecific and may include nausea, vomiting, abdominal cramps and diarrhoea, fatigue, myalgias, arthralgias, weakness, fever, dizziness, weight loss, amenorrhoea, decreased libido and depression.\n\nNote 3: Adrenal insufficiency may be acute or chronic. Acute adrenal insufficiency may present as an adrenal crisis. Primary adrenal insufficiency is also known as Addison disease.\n\n(3) While adrenal insufficiency attracts ICD‑10‑AM code E27.1, E27.2, E27.3, E27.4, E89.6, A18.7 or A39.1, in applying this Statement of Principles the meaning of adrenal insufficiency is that given in subsection (2).\n\n(4) For subsection (3), a reference to an ICD-10-AM code is a reference to the code assigned to a particular kind of injury or disease in The International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification (ICD-10-AM), Tenth Edition, effective date of 1 July 2017, copyrighted by the Independent Hospital Pricing Authority, ISBN 978-1-76007-296-4.\n\nDeath from adrenal insufficiency\n\n(5) For the purposes of this Statement of Principles, adrenal insufficiency, in relation to a person, includes death from a terminal event or condition that was contributed to by the person's adrenal insufficiency.\n\nNote: terminal event is defined in the Schedule 1 – Dictionary.\n\n8 Basis for determining the factors\n\nOn the sound medical‑scientific evidence available, the Repatriation Medical Authority is of the view that it is more probable than not that adrenal insufficiency and death from adrenal insufficiency can be related to relevant service rendered by veterans or members of the Forces under the VEA, or members under the MRCA.\n\nNote: MRCA, relevant service and VEA are defined in the Schedule 1 – Dictionary.\n\n9 Factors that must exist\n\nAt least one of the following factors must exist before it can be said that, on the balance of probabilities, adrenal insufficiency or death from adrenal insufficiency is connected with the circumstances of a person's relevant service:\n\n(1) having an autoimmune disorder involving the adrenal glands at the time of the clinical onset of adrenal insufficiency;\n\n(2) having infiltration of the adrenal glands due to a disorder from the specified list of infiltrative disorders at the time of the clinical onset of adrenal insufficiency;\n\nNote: specified list of infiltrative disorders is defined in the Schedule 1 - Dictionary.\n\n(3) having infection with human immunodeficiency virus before the clinical onset of adrenal insufficiency;\n\n(4) having an injury or surgery to:\n\n(a) both adrenal glands, or\n\n(b) a single adrenal gland:\n\n(i) where there is only one functional adrenal gland; or\n\n(ii) as surgical treatment for Cushing syndrome;\n\n within the one year before the clinical onset of adrenal insufficiency;\n\n(5) having haemorrhage or infarction of:\n\n(a) both adrenal glands, or\n\n(b) a single functional adrenal gland, where there is only one functional adrenal gland;\n\n within the one year before the clinical onset of adrenal insufficiency;\n\nNote: Common causes of adrenal haemorrhage or infarction include trauma to the adrenal gland, heparin-induced thrombocytopaenia, anticoagulant therapy, antiphospholipid syndrome, sepsis, malignancy and haematological disorder. \n\n(6) having an infection of the adrenal glands with an organism from the specified list of infectious organisms at the time of the clinical onset of adrenal insufficiency;\n\nNote: specified list of infectious organisms is defined in the Schedule 1 - Dictionary. \n\n(7) being treated with a drug or a drug from a class of drugs from Specified List 1 of drugs within the three months before the clinical onset of adrenal insufficiency;\n\nNote: Specified List 1 of drugs is defined in the Schedule 1 - Dictionary. \n\n(8) having glucocorticoid therapy as specified, before the clinical onset of adrenal insufficiency, and where the glucocorticoid therapy as specified has ceased or decreased, the last dose of the therapy was received within the one year before the clinical onset of adrenal insufficiency;\n\nNote: glucocorticoid therapy as specified is defined in the Schedule 1 - Dictionary. \n\n(9) being treated with medroxyprogesterone acetate or megestrol acetate for a malignant disease or human immunodeficiency virus infection:\n\n(a) for a continuous period of at least four weeks before the clinical onset of adrenal insufficiency; and\n\n(b) where such treatment has ceased, the last dose was received within the three months before the clinical onset of adrenal insufficiency;\n\n(10) having hypopituitarism with adrenocorticotrophic hormone deficiency, at the time of the clinical onset of adrenal insufficiency;\n\n(11) having a critical illness or injury within the one year before the clinical onset of adrenal insufficiency;\n\nNote: critical illness or injury is defined in the Schedule 1 - Dictionary. \n\n(12) for adrenal crisis only, having an acute, severe stressor within the seven days before the clinical onset of adrenal insufficiency;\n\nNote: acute, severe stressor and adrenal crisis are defined in the Schedule 1 - Dictionary. \n\n(13) having an autoimmune disorder involving the adrenal glands at the time of the clinical worsening of adrenal insufficiency;\n\n(14) having infiltration of the adrenal glands due to a disorder from the specified list of infiltrative disorders at the time of the clinical worsening of adrenal insufficiency;\n\nNote: specified list of infiltrative disorders is defined in the Schedule 1 - Dictionary.\n\n(15) having infection with human immunodeficiency virus before the clinical worsening of adrenal insufficiency;\n\n(16) having an injury or surgery to:\n\n(a) both adrenal glands, or\n\n(b) a single adrenal gland:\n\n(i) where there is only one functional adrenal gland; or\n\n(ii) as surgical treatment for Cushing syndrome;\n\n within the one year before the clinical worsening of adrenal insufficiency;\n\n(17) having haemorrhage or infarction of:\n\n(a) both adrenal glands, or\n\n(b) a single functional adrenal gland, where there is only one functional adrenal gland;\n\n within the one year before the clinical worsening of adrenal insufficiency;\n\nNote: Common causes of adrenal haemorrhage or infarction include trauma to the adrenal gland, heparin-induced thrombocytopaenia, anticoagulant therapy, antiphospholipid syndrome, sepsis, malignancy and haematological disorder. \n\n(18) having an infection of the adrenal glands with an organism from the specified list of infectious organisms at the time of the clinical worsening of adrenal insufficiency;\n\nNote: specified list of infectious organisms is defined in the Schedule 1 - Dictionary. \n\n(19) being treated with a drug or a drug from a class of drugs from Specified List 1 of drugs within the three months before the clinical worsening of adrenal insufficiency;\n\nNote: Specified List 1 of drugs is defined in the Schedule 1 - Dictionary. \n\n(20) having glucocorticoid therapy as specified, before the clinical worsening of adrenal insufficiency:\n\n(a) where the glucocorticoid therapy as specified is not being taken for the treatment of adrenal insufficiency; and\n\n(b) where the glucocorticoid therapy as specified has ceased or decreased, the last dose of the therapy was received within the one year before the clinical worsening of adrenal insufficiency;\n\nNote: glucocorticoid therapy as specified is defined in the Schedule 1 - Dictionary. \n\n(21) being treated with medroxyprogesterone acetate or megestrol acetate for a malignant disease or human immunodeficiency virus infection:\n\n(a) for a continuous period of at least four weeks before the clinical worsening of adrenal insufficiency; and\n\n(b) where such treatment has ceased, the last dose was received within the three months before the clinical worsening of adrenal insufficiency;\n\n(22) having hypopituitarism with adrenocorticotrophic hormone deficiency, at the time of the clinical worsening of adrenal insufficiency;\n\n(23) having a critical illness or injury within the one year before the clinical worsening of adrenal insufficiency;\n\nNote: critical illness or injury is defined in the Schedule 1 - Dictionary. \n\n(24) for adrenal crisis only, having an acute, severe stressor within the seven days before the clinical worsening of adrenal insufficiency;\n\nNote: acute, severe stressor and adrenal crisis are defined in the Schedule 1 - Dictionary. \n\n(25) inability to obtain appropriate clinical management for adrenal insufficiency.\n\n10 Relationship to service\n\n(1) The existence in a person of any factor referred to in section 9, must be related to the relevant service rendered by the person.\n\n(2) The factors set out in subsections 9(13) to 9(25) apply only to material contribution to, or aggravation of, adrenal insufficiency where the person's adrenal insufficiency was suffered or contracted before or during (but did not arise out of) the person's relevant service.\n\n11 Factors referring to an injury or disease covered by another Statement of Principles\n\nIn this Statement of Principles:\n\n(1) if a factor referred to in section 9 applies in relation to a person; and\n\n(2) that factor refers to an injury or disease in respect of which a Statement of Principles has been determined under subsection 196B(3) of the VEA;\n\nthen the factors in that Statement of Principles apply in accordance with the terms of that Statement of Principles as in force from time to time.\n\n \n\n \n\nSchedule 1 - Dictionary \n\nNote: See Section 6\n\n2 Definitions\n\nIn this instrument:\n\nacute, severe stressor means a physical or psychological stimulus or event that causes a sudden, intense psychological or physical response.\n\nNote: Examples of acute, severe stressors include:\n\n(a) abrupt cessation or lowering of glucocorticoid therapy;\n\n(b) acute hepatic failure;\n\n(c) alcohol intoxication;\n\n(d) atrial fibrillation;\n\n(e) being exposed to an environment of extreme heat during a heatwave;\n\n(f) critical illness or injury;\n\n(g) dehydration;\n\n(h) experiencing a category 1A stressor;\n\n(i) experiencing an acute, severe, emotional stressor;\n\n(j) febrile illness;\n\n(k) gastrointestinal infection;\n\n(l) long distance flight;\n\n(m) migraine;\n\n(n) oesophageal variceal bleeding;\n\n(o) physical trauma or injury;\n\n(p) serious acute illness;\n\n(q) surgery;\n\n(r) thyrotoxicosis;\n\n(s) undertaking physical activity of five METs or more; and\n\n(t) wasp or bee sting.\n\nNote: category 1A stressor, critical illness or injury, extreme heat and MET are also defined in the Schedule 1 – Dictionary.\n\n adrenal crisis means a constellation of symptoms that indicate severe adrenal insufficiency of rapid onset causing acute haemodynamic decompensation. Characteristic symptoms and signs are hypotension, tachycardia, hypovolaemia (shock), lethargy, hypoglycaemia, disorientation, impaired consciousness, seizures and coma.\n\nNote 1: Adrenal crisis is a medical emergency that requires treatment with injectable hydrocortisone and fluid support. Adrenal crisis is also known as an Addisonian crisis.\n\nNote 2: Adrenal crisis may be the first presentation of undiagnosed adrenal insufficiency, or may complicate existing chronic adrenal insufficiency.\n\n adrenal insufficiency—see subsection 7(2).\n\n category 1A stressor means one of the following severe traumatic events:\n\n(a) experiencing a life-threatening event;\n\n(b) being subject to a serious physical attack or assault including rape and sexual molestation; or\n\n(c) being threatened with a weapon, being held captive, being kidnapped or being tortured.\n\n critical illness or injury means any physical injury or illness requiring mechanical ventilation support or admission to an intensive care unit, or which causes septicaemia, adult respiratory distress syndrome, acute renal tubular necrosis, disseminated intravascular coagulation or multiple organ failure.\n\n equivalent glucocorticoid therapy means a glucocorticoid in the following table, at the doses specified in the table, or a therapeutically equivalent dose of another glucocorticoid:\n\n| Glucocorticoid | Minimum cumulative
dose (milligrams)
| Minimum average
rate (milligrams/day) |\n| --- | --- | --- |\n| betamethasone | 18 | 0.6 |\n| cortisone | 750 | 25 |\n| dexamethasone | 22 | 0.7 |\n| methylprednisolone | 120 | 4 |\n| paramethasone | 60 | 2 |\n| prednisolone | 150 | 5 |\n| prednisone | 150 | 5 |\n| triamcinolone | 120 | 4 |\n\n\n equivalent inhaled glucocorticoid means:\n\n(a) 800 micrograms of beclomethasone;\n\n(b) 400 micrograms of fluticasone furoate;\n\n(c) 1 000 micrograms of fluticasone propionate;\n\n(d) 4 000 micrograms of triamcinolone; or\n\n(e) a therapeutically equivalent dose of another inhaled glucocorticoid.\n\n extreme heat means 40 degrees Celsius or above.\n\n glucocorticoid therapy as specified means:\n\n(a) applying a high or very high potency topical glucocorticoid to at least 10% of total skin surface area, daily, for a continuous period of at least three months; or\n\n(b) inhaling at least 1 600 micrograms of budesonide, or equivalent inhaled glucocorticoid, daily, for a continuous period of at least three months; or\n\n(c) taking:\n\n(i) hydrocortisone, orally or by injection:\n\n(A) to a cumulative dose of at least 600 milligrams; and\n\n(B) at a minimum dose rate averaging 20 milligrams per day, or\n\n(ii) equivalent glucocorticoid therapy, orally or by injection; or\n\n(d) using a glucocorticoid concurrently with a drug, daily, for at least four weeks, where that drug can inhibit the activity of the metabolising enzyme cytochrome P450 3A4 by at least 30% (moderate to strong inhibition); or\n\n(e) using a glucocorticoid concurrently with a drug from Specified List 2 of drugs, daily, for a continuous period of at least four weeks; or\n\n(f) using an ocular glucocorticoid, daily, for a continuous period of at least six months; or\n\n(g) using an intranasal glucocorticoid, at an average daily dose exceeding 400 micrograms of betamethasone 0.1%, or equivalent intranasal glucocorticoid, for a continuous period of at least six months; or\n\n(h) using glucocorticoid containing enemas, daily, for a continuous period of at least six months; or\n\n(i) taking any glucocorticoid therapy that causes Cushing syndrome.\n\nNote: equivalent glucocorticoid therapy, equivalent inhaled glucocorticoid, high or very high potency topical glucocorticoid and Specified List 2 of drugs are also defined in the Schedule 1 – Dictionary.\n\n high or very high potency topical glucocorticoid means:\n\n(a) betamethasone dipropionate 0.05%;\n\n(b) betamethasone valerate 0.1%;\n\n(c) clobetasol proprionate 0.05%;\n\n(d) diflucortolone valerate 0.1%;\n\n(e) fluocinolone acetonide 0.025%;\n\n(f) methylprednisolone 0.1%;\n\n(g) mometasone 0.1%;\n\n(h) triamcinolone acetonide 0.5%; or\n\n(i) another topical glucocorticoid of equivalent potency.\n\n iron overload means an accumulation of excess iron in tissues and organs which has been confirmed by elevated ferritin or transferrin saturation levels. Causes include haemochromatosis or blood transfusions.\n\n MET means a unit of measurement of the level of physical exertion. 1 MET = 3.5 ml of oxygen/kg of body weight per minute, 1.0 kcal/kg of body weight per hour or resting metabolic rate.\n\n MRCA means the Military Rehabilitation and Compensation Act 2004.\n\n relevant service means:\n\n(a) eligible war service (other than operational service) under the VEA;\n\n(b) defence service (other than hazardous service and British nuclear test defence service) under the VEA; or\n\n(c) peacetime service under the MRCA.\n\nNote: MRCA and VEA are also defined in the Schedule 1 - Dictionary.\n\n Specified List 1 of drugs means:\n\n(a) aminoglutethimide;\n\n(b) imidazole antifungals;\n\n(c) busulfan;\n\n(d) etomidate; \n\n(e) immune checkpoint inhibitors;\n\n(f) metyrapone; \n\n(g) mifepristone; \n\n(h) mitotane;\n\n(i) rifampicin;\n\n(j) suramin; or\n\n(k) treosulfan.\n\n Specified List 2 of drugs means:\n\n(a) amprenavir;\n\n(b) atazanavir;\n\n(c) clarithromycin;\n\n(d) darunavir;\n\n(e) delavirdine;\n\n(f) erythromycin;\n\n(g) fluconazole;\n\n(h) fosamprenavir;\n\n(i) indinavir;\n\n(j) itraconazole;\n\n(k) ketoconazole;\n\n(l) lopinavir;\n\n(m) nelfinavir;\n\n(n) posaconazole; \n\n(o) ritonavir;\n\n(p) saquinavir;\n\n(q) telithromycin;\n\n(r) tipranavir; or\n\n(s) voriconazole.\n\n specified list of infectious organisms means:\n\n(a) Blastomyces dermatitidis;\n\n(b) Coccidioides immitis;\n\n(c) Coccidioides posadasii;\n\n(d) Cryptococcosis neoformans;\n\n(e) cytomegalovirus;\n\n(f) Echinococcus granulosus;\n\n(g) herpes simplex virus;\n\n(h) Histoplasma capsulatum;\n\n(i) Mycobacterium avium-intracellulare;\n\n(j) Mycobacterium kansasii;\n\n(k) Mycobacterium tuberculosis;\n\n(l) Nocardia spp;\n\n(m) Paracoccidioides brasiliensis;\n\n(n) Pneumocystis carinii; or\n\n(o) Toxoplasmosis gondii.\n\n specified list of infiltrative disorders means:\n\n(a) a primary or metastatic neoplasm;\n\n(b) amyloidosis;\n\n(c) iron overload; or\n\n(d) sarcoidosis.\n\nNote: iron overload is also defined in the Schedule 1 - Dictionary.\n\n terminal event means the proximate or ultimate cause of death and includes the following:\n\n(a) pneumonia;\n\n(b) respiratory failure;\n\n(c) cardiac arrest;\n\n(d) circulatory failure; or\n\n(e) cessation of brain function.\n\n VEA means the Veterans' Entitlements Act 1986.\n\n \n\n \n","sortOrder":0}],"analysis":{"flash_summary":{"complexity_score":6,"scope_assessment":{"changed":true,"description":"The instrument expressly repeals the prior Statement of Principles No. 75 of 2009 (s4) and replaces it with updated criteria. It narrows/frames scope by explicitly including drug‑induced adrenal insufficiency and excluding congenital/heritable forms (s7(2)(b)–(c)), and by specifying detailed drug, infection, infiltrative and glucocorticoid exposure thresholds and temporal windows that determine when a condition is connected to relevant service (s9, Schedule). It applies to claims under the VEA and MRCA (s5)."},"complexity_factors":["Extensive medical definitions and clinical criteria for adrenal insufficiency, adrenal crisis and acute stressors (s7(2), Schedule definitions).","Multiple specified lists requiring medical identification: drugs (Specified Lists 1 & 2), infectious organisms, and infiltrative disorders (Schedule).","Quantitative dose and duration thresholds for glucocorticoid exposure and equivalents (Schedule: equivalent glucocorticoid, equivalent inhaled glucocorticoid, glucocorticoid therapy as specified).","Several differing temporal windows for causation and worsening (e.g. within one year, three months, seven days) across factors (s9).","Different causal concepts: initial causation, material contribution, aggravation and clinical worsening, with limiting rules for when each applies (s9, s10).","Cross‑references to other Statements of Principles that can alter applicable factors (s11).","Legal application confined to specific claim schemes (VEA s120B and MRCA s339) which affects evidentiary and administrative processes (s5).","Repeal and replacement of a prior Statement, implying practitioners must use updated criteria (s4)."],"plain_english_summary":"This Statement of Principles tells the Repatriation Medical Authority which medical findings, drug exposures and time windows establish, on the balance of probabilities, that adrenal insufficiency (including drug‑induced, excluding congenital/heritable forms) or death from it is related to a person's service. It applies to claims under the Veterans' Entitlements Act and the Military Rehabilitation and Compensation Act. The instrument lists specific clinical definitions, specified infectious organisms and drugs, glucocorticoid dose/duration thresholds and temporal limits that, if linked to relevant service, satisfy causation."},"flash_summary_failed":{"failed":true,"reason":"Unauthenticated. Configure AI_GATEWAY_API_KEY or use a provider module. Learn more: https://ai-sdk.dev/unauthenticated-ai-gateway","source":"analysis-cron"},"kimi_summary":{"content_quality":"ok","complexity_score":6,"scope_assessment":{"changed":false,"description":"This is a standard Statement of Principles instrument made under the Veterans' Entitlements Act 1986. It replaces a 2009 version concerning the same medical condition (adrenal insufficiency) and operates within the established statutory framework for determining service-related injury and disease. The scope remains consistent with the original legislative intent of providing medical criteria for veterans' compensation claims."},"complexity_factors":["25 distinct factors with specific temporal requirements (e.g., 'within one year before', 'within three months before', 'within seven days before')","Multiple defined terms in Schedule 1 (approximately 20+ definitions including nested definitions)","Cross-references between factors and dictionary definitions (e.g., 'specified list of infiltrative disorders', 'glucocorticoid therapy as specified')","Complex medical dosing tables for glucocorticoid equivalence with multiple administration routes (oral, inhaled, topical, ocular, intranasal, enema)","Conditional logic within factors (e.g., factor 9 requires both continuous treatment AND recency of last dose)","Bifurcated structure covering both 'clinical onset' (factors 1-12) and 'clinical worsening' (factors 13-25) with slightly different requirements","Specific exclusion of heritable/congenital forms in the definition","Reference to external classification systems (ICD-10-AM Tenth Edition)","Nested definitions (e.g., 'acute severe stressor' includes 'category 1A stressor' and 'critical illness or injury', which are themselves defined)"],"plain_english_summary":"This instrument sets the medical criteria the Repatriation Medical Authority uses to decide whether adrenal insufficiency in veterans and current/former defence members is service-related, replacing the 2009 guidance. It lists 25 factors (covering new onset and worsening) and applies the \"balance of probabilities\" test.\n\nIt matters because meeting at least one listed medical link—e.g., autoimmune damage, infection, trauma, certain drugs, or lack of treatment—is typically required for entitlement to compensation."}},"importantCases":[],"_links":{"self":"/api/acts/statement-of-principles-concerning-adrenal-insufficiency-balance-of-probabilities-no-72-of-2018","history":"/api/acts/statement-of-principles-concerning-adrenal-insufficiency-balance-of-probabilities-no-72-of-2018/history","analysis":"/api/acts/statement-of-principles-concerning-adrenal-insufficiency-balance-of-probabilities-no-72-of-2018/analysis","conflicts":"/api/acts/statement-of-principles-concerning-adrenal-insufficiency-balance-of-probabilities-no-72-of-2018/conflicts","importantCases":"/api/acts/statement-of-principles-concerning-adrenal-insufficiency-balance-of-probabilities-no-72-of-2018/important-cases","documents":"/api/acts/statement-of-principles-concerning-adrenal-insufficiency-balance-of-probabilities-no-72-of-2018/documents"}}